MSM (Methylsulfonylmethane) is a natural, sulfur-rich compound that has earned a devoted following in skincare for its powerful anti-inflammatory, collagen-boosting, and skin-repairing properties. Often found in powder or crystalline form, it's used both topically and internally (as a supplement), but in skincare, it shines as a dermal rejuvenator.

What is MSM Powder?

MSM powder is considered very safe, non-toxic, and non-comedogenic. It’s incredibly beneficial for aging skin (collagen loss, fine lines, dullness), acne-prone skin (inflammation, post-inflammatory hyperpigmentation), sensitive or inflamed skin (rosacea, dermatitis, redness) and stressed skin (post-procedure, sun damage, or compromised barriers).

How is MSM Powder used in skincare?

• Serums, creams and masks: Commonly blended into anti-aging, acne-fighting, and brightening products. It’s also added to DIY formulations for those who want a highly customized routine.
• Transdermal gels and lotions: Used in therapeutic gels for joint pain, but these can have skin benefits too—especially for inflamed or damaged skin.
• Supplements for skin health: MSM taken internally may enhance the effects of topical application—think of it as working from the inside out.

What are the benefits of MSM Powder for your complexion and skin microbiome?

MSM (Methylsulfonylmethane) can be supportive of the skin microbiome, especially when used in formulas designed to reduce inflammation, balance the skin barrier, and aid repair. While MSM doesn’t directly feed or colonize microbiota (like prebiotics or probiotics do), it plays an indirect but powerful role in maintaining the conditions needed for a healthy microbiome:

• Supports Collagen & Keratin Production: MSM delivers bioavailable sulfur, a building block for collagen and keratin, which improves skin elasticity and firmness, reduces fine lines and sagging, as well as strengthens the skin’s structural integrity.
• Fades Hyperpigmentation & Brightens Skin: MSM is known to inhibit melanin overproduction, especially when paired with vitamin C or niacinamide. This helps fade age spots, acne marks, and uneven tone.
• Strengthens the Skin Barrier: A strong barrier creates a stable home for commensal (good) microbes. MSM enhances production of collagen, keratin, and lipids, which reinforce the stratum corneum, reduce trans-epidermal water loss (TEWL) and protect against pathogenic bacterial overgrowth.
• Calms Inflammation & Redness: MSM is especially beneficial for rosacea, cystic acne and eczema—helping to soothe inflamed skin by modulating inflammatory cytokines.
• Accelerates Wound Healing & Skin Repair: MSM promotes cell regeneration and reduces scarring—aiding in recovery after skin stress (acids, sun, acne, or treatments).
• Reduces Inflammation: Many anti-inflammatory agents—especially synthetic ones—can disrupt microbial harmony. MSM soothes irritation without sterilizing or stripping the skin, making it gentler on microbial communities.
• Increases Skin Permeability: It acts as a carrier molecule, improving the absorption of other active ingredients into the deeper layers of the skin. This is why you’ll often find it in formulas alongside ingredients like vitamin C, peptides, or botanical extracts.

Common Pairings with MSM Powder (Methylsulfonylmethane):

MSM often acts synergistically, especially with:

• Vitamin C: boosts collagen production + brightening
• Zinc and sulfur-rich botanicals: acne control
• Retinol or exfoliants: gentle offset to irritation
• Peptides: deeper penetration for firming and repair